Related Experiment Video
Updated: May 25, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Synthesis and evaluation of novel monosubstituted sulfonylurea derivatives as antituberculosis agents
1State-Key Laboratory of Elemento-Organic Chemistry, National Pesticide Engineering Research Center(Tianjin), Nankai University, Tianjin 300071, China.
Abstract:
A series of novel monosubstituted sulfonylurea derivatives 10a-y were synthesized and characterized by (1)H NMR, (13)C NMR and HRMS. These compounds were evaluated against Mycobacterium tuberculosis H37Rv in vitro. The results showed compounds 10f, 10k and 10s exhibited moderate antituberculosis activities with MIC values in the range of 20-100 mg/L. Compounds 10b and 10o displayed good antituberculosis activities (MIC 10 mg/L), which were comparable with that of the sulfometuron methyl. Both of the two compounds showed little cytotoxicities, with an IC(50) against THP-1 cells greater than 100 mg/L.
Related Concept Videos
Oral Hypoglycemic Agents: Sulfonylureas
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Amines to Sulfonamides: The Hinsberg Test
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
Antihypertensive Drugs: Thiazide-Class Diuretics
Anthelminthic Agents
Preparation and Reactions of Sulfides
