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Polymorphisms in the SLC11A1 gene and tuberculosis risk: a meta-analysis update
1Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Genetic variations in the SLC11A1 gene, including D543N and INT4, are linked to an increased risk of tuberculosis (TB). This association is particularly strong in Asian populations and for pulmonary TB.
Area of Science:
- Genetics
- Immunology
- Epidemiology
Background:
- Polymorphisms in the SLC11A1 gene have been investigated for their association with tuberculosis (TB).
- Previous replication studies yielded inconsistent results, necessitating a comprehensive evaluation.
Purpose of the Study:
- To evaluate the genetic risk of specific SLC11A1 polymorphisms (D543N, 3'UTR TGTG ins/del, INT4, [GT]n) for TB.
- To consolidate evidence from multiple studies through meta-analysis.
Main Methods:
- A meta-analysis of 82 case-control studies from 35 articles was conducted.
- Association between four SLC11A1 polymorphisms and TB risk was analyzed.
Main Results:
- All four SLC11A1 polymorphisms (D543N, 3'UTR TGTG ins/del, INT4, [GT]n) were associated with an increased risk of TB.
- Significant increased risks were observed in Asian populations and for pulmonary TB (PTB) across all polymorphisms.
- D543N polymorphism showed an increased risk for extra-pulmonary TB (EPTB).
Conclusions:
- SLC11A1 gene polymorphisms contribute to the risk of developing TB, including both PTB and EPTB.
- The genetic risk is particularly pronounced in Asian individuals.
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