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Roles of transforming growth factor-β in graft-versus-host and graft-versus-tumor effects

Cédric Carli1, Martin Giroux, Jean-Sébastien Delisle

  • 1Maisonneuve-Rosemont Hospital Research Center, Montreal, Canada.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|February 14, 2012
PubMed

Transforming growth factor (TGF)-β is a pleiotropic cytokine with widespread and profound effects on immune cells. Consequently, it has generated considerable interest in relation to the immunologic outcomes after allogeneic hematopoietic cell transplantation. The TGF-β pathway has been shown to be an important modulator of alloimmunity, with direct consequences on graft-versus-host disease pathophysiology and graft-versus-tumor response. The TGF-β-related effects can be both beneficial and detrimental to the host, underscoring the complexity of TGF-β biology. This article reviews the evidence linking TGF-β to alloimmune responses in allogeneic hematopoietic cell transplantation and highlights foreseeable strategies that would maximize the beneficial effects of TGF-β pathway modulation on both graft-versus-host disease pathophysiology and the graft-versus-tumor effect.

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