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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Related Experiment Video

Updated: May 25, 2026

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
09:29

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

General RBP expression in human tissues as a function of age.

Kiyoshi Masuda1, Yuki Kuwano, Kensei Nishida

  • 1Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, 770-8503, Japan. kiyoshim@basic.med.tokushima-u.ac.jp

Ageing Research Reviews
|February 14, 2012
PubMed
Summary

RNA-binding proteins (RBPs) regulate gene expression. Their tissue- and age-dependent expression in humans is largely unknown, despite roles in aging. Discrepancies exist between cell models and human tissues.

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Robust Comparison of Protein Levels Across Tissues and Throughout Development Using Standardized Quantitative Western Blotting
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Robust Comparison of Protein Levels Across Tissues and Throughout Development Using Standardized Quantitative Western Blotting

Published on: April 9, 2019

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Last Updated: May 25, 2026

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09:29

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Monitoring of Ubiquitin-proteasome Activity in Living Cells Using a Degron (dgn)-destabilized Green Fluorescent Protein (GFP)-based Reporter Protein
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Robust Comparison of Protein Levels Across Tissues and Throughout Development Using Standardized Quantitative Western Blotting
08:13

Robust Comparison of Protein Levels Across Tissues and Throughout Development Using Standardized Quantitative Western Blotting

Published on: April 9, 2019

Area of Science:

  • Molecular Biology
  • Genetics
  • Aging Research

Background:

  • Gene expression exhibits significant tissue-specific and age-dependent variations.
  • RNA-binding proteins that regulate mRNA turnover and/or translation (TTR-RBPs) are crucial regulators of protein subsets.
  • Understanding TTR-RBP expression in human tissues across age is vital for comprehending aging processes.

Purpose of the Study:

  • To review current knowledge on the tissue- and age-dependent expression of human TTR-RBPs.
  • To highlight the physiological roles of TTR-RBPs in human aging.
  • To address discrepancies between in vitro aging models and human tissue data.

Main Methods:

  • Analysis of TTR-RBP expression using human tissue microarrays.
  • Comparison of TTR-RBP levels in senescent human diploid fibroblasts (HDFs) with those in human tissues from individuals of various ages.
  • Literature review of existing data on human TTR-RBP expression patterns.

Main Results:

  • TTR-RBP expression patterns are highly variable across different human tissues and with advancing age.
  • Significant differences were observed in TTR-RBP levels between senescent HDFs and aged human tissues.
  • These findings suggest potential limitations of HDFs as a sole in vitro model for studying age-related TTR-RBP changes.

Conclusions:

  • Human TTR-RBP expression is complex, varying by tissue type and age.
  • Current in vitro aging models may not fully recapitulate age-dependent TTR-RBP dynamics observed in vivo.
  • Further research is needed to elucidate the precise roles of TTR-RBPs in human aging across different tissues.