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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

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Related Experiment Video

Updated: May 25, 2026

Myo-mechanical Analysis of Isolated Skeletal Muscle
08:42

Myo-mechanical Analysis of Isolated Skeletal Muscle

Published on: February 22, 2011

[Steroid-induced myopathy].

Serge Perrot1, Claire Le Jeunne

  • 1Université Paris Descartes, Hôtel Dieu, service de médecine interne et thérapeutique, Inserm U 987, 75004 Paris, France. Serge.perrot@htd.aphp.fr

Presse Medicale (Paris, France : 1983)
|February 14, 2012
PubMed
Summary

Steroid-induced myopathy is a common adverse effect of steroid therapy. This condition presents as either acute or chronic muscle weakness, with prevention through steroid dose reduction being key.

Area of Science:

  • Endocrinology
  • Neurology
  • Pathology

Context:

  • Steroid myopathy is a frequent adverse effect of corticosteroid therapy.
  • Clinical manifestations vary, including acute and chronic forms.
  • Diagnosis relies primarily on clinical presentation.

Purpose:

  • To describe the clinical features, diagnosis, pathophysiology, and treatment of steroid-induced myopathy.
  • To highlight the importance of recognizing steroid myopathy as an adverse effect.
  • To emphasize prevention strategies.

Summary:

  • Steroid myopathy presents as acute (rare, high-dose) or chronic (common, insidious proximal weakness).
  • Diagnosis is clinical; muscle biopsy is rarely indicated due to nonspecific findings.
  • Pathophysiology involves altered protein metabolism, cellular transcription, and growth factors like IGF-1 and myostatin.

Related Experiment Videos

Last Updated: May 25, 2026

Myo-mechanical Analysis of Isolated Skeletal Muscle
08:42

Myo-mechanical Analysis of Isolated Skeletal Muscle

Published on: February 22, 2011

  • Treatment is nonspecific, focusing on preventing myopathy by reducing steroid dosage.

    • Impact:

    • Improved recognition and management of steroid-induced myopathy.
    • Guidance on diagnostic approaches, minimizing unnecessary invasive procedures.
    • Informed clinical decisions regarding steroid therapy and patient monitoring.
    • Potential for reduced morbidity associated with long-term steroid use.