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A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
08:12

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

[Cerebral vasculitides]

Hubert de Boysson1, Anthony Faivre, Christian Pagnoux

  • 1CHU Côte-de-Nacre, université de Caen, pôle de médecine interne et d'immunologie clinique, avenue de la Côte-de-Nacre, 14033 Caen cedex 9, France.

Presse Medicale (Paris, France : 1983)
|February 14, 2012
PubMed

Insights

Diagnosing cerebral vasculitis requires ruling out secondary causes through comprehensive clinical, biological, and radiological evaluation. Definitive diagnosis often necessitates a leptomeningeal biopsy when uncertainty persists.

Area of Science:

  • Neurology
  • Immunology
  • Radiology

Background:

  • Cerebral vasculitides encompass primary central nervous system vasculitis and secondary forms linked to systemic diseases, infections, malignancies, or toxic exposures.
  • Suspected cerebral vasculitis mandates an exhaustive diagnostic workup to exclude diverse secondary etiologies.

Purpose of the Study:

  • To outline the diagnostic approach for cerebral vasculitis.
  • To emphasize the importance of differentiating primary from secondary forms and the role of specific investigations.

Main Methods:

  • Diagnosis typically integrates clinical presentation, biological markers, and neuroimaging (MRI).
  • Cerebrospinal fluid examination and MRI can help rule out the condition.
  • Leptomeningeal biopsy is considered definitive, particularly in cases of diagnostic uncertainty or underlying systemic disease.

Main Results:

  • A combination of clinical, biological, and radiological findings often suggests cerebral vasculitis.
  • Normal MRI and cerebrospinal fluid findings may exclude the diagnosis.
  • Leptomeningeal biopsy provides definitive diagnosis when suspicion remains high.

Conclusions:

  • Early diagnosis and prompt treatment of cerebral vasculitis improve prognosis.
  • Treatment for secondary vasculitis targets the underlying cause, often supplemented by corticosteroids and immunosuppressants.
  • Consensus on treatment for primary central nervous system vasculitis is lacking.

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