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Related Experiment Video

Updated: May 25, 2026

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
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Repeated mild hypoxic exposures decrease anxiety-like behavior in the adult mouse together with an increased brain

Claire Leconte1, Marianne Léger, Michel Boulouard

  • 1Université de Caen Basse-Normandie, UMR 6232 CI-NAPS, CERVOxy team, Hypoxia and cerebrovascular pathophysiology, GIP CYCERON, F-14074 Caen, France.

Behavioural Brain Research
|February 14, 2012
PubMed
Summary
This summary is machine-generated.

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Mild hypoxia exposure in mice reduced anxiety-like behaviors and modestly improved non-spatial memory. This suggests potential therapeutic benefits of mild hypoxia, mediated by genes like adrenomedullin.

Area of Science:

  • Neuroscience
  • Physiology

Background:

  • Severe hypoxia causes neuronal death and neurological issues.
  • Mild hypoxia can trigger beneficial adaptive responses.

Purpose of the Study:

  • To investigate the impact of mild hypoxia on cognitive and emotional behavior in adult mice.
  • To explore the role of hypoxia-inducible factor-1 (HIF-1) target genes in mediating these effects.

Main Methods:

  • Adult mice were exposed to mild hypoxia (8% O2) or normoxia for 6 weeks.
  • Behavioral tests, including the light/dark transition test, were conducted during the final 3 weeks.
  • Adrenomedullin and vascular endothelial growth factor (VEGF) mRNA expression were measured.

Main Results:

  • Mild hypoxia decreased anxiety-like behavior.

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  • Non-spatial recognition memory was modestly enhanced.
  • Adrenomedullin mRNA expression increased, while VEGF mRNA expression showed a delayed increase.
  • Spatial learning and locomotor activity remained unchanged.

    • Conclusions:

    • Repeated mild hypoxic exposure can reduce anxiety-related behaviors.
    • Adrenomedullin, a HIF-1 target gene, is a potential mediator of these beneficial effects.