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Updated: May 25, 2026
08:25
Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
Published on: April 11, 2018
Comp Plan: A computer program to generate dose and radiobiological metrics from dose-volume histogram files.
Lois Charlotte Holloway1, Julie-Anne Miller, Shivani Kumar
1Liverpool and Macarthur Cancer Therapy Centres, Sydney, Australia. lois.holloway@sswahs.nsw.gov.au
Summary
Comp Plan is a MATLAB program that simplifies calculating radiobiological metrics for radiation therapy planning. It efficiently processes dose-volume histogram data, aiding in treatment analysis and statistical evaluation.
Area of Science:
- Radiation Oncology
- Medical Physics
- Computational Biology
Background:
- Treatment planning studies necessitate extensive dose and radiobiological metric calculations.
- Streamlining these complex computations is crucial for efficient research and clinical application.
Purpose of the Study:
- To develop a user-friendly computer program, Comp Plan, for automating dose and radiobiological metric calculations.
- To facilitate the analysis of treatment planning data, including adjustments for fraction size and boost doses.
Main Methods:
- Developed Comp Plan using MATLAB to compute metrics like equivalent uniform dose, tumor control probability, and normal tissue complication probability from dose-volume histogram data.
- Implemented the linear quadratic model for adjusted fraction size calculations and included functionality for homogeneous boost doses.
- Designed the output to be compatible with Excel for straightforward statistical analysis.
Main Results:
- Comp Plan successfully calculated various dose and radiobiological metrics, supporting both original and adjusted fraction size scenarios.
- Verification through independent calculations confirmed the program's accuracy.
- A lung treatment planning study involving 45 plans and 7 structures was analyzed in approximately 5 minutes.
Conclusions:
- Comp Plan significantly streamlines the calculation of essential radiobiological metrics in radiation therapy planning.
- The program enhances efficiency and facilitates statistical analysis, making it a valuable tool for researchers and clinicians.
- The freely available code promotes wider adoption and collaboration in the field.
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