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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Temperature and neuronal circuit function: compensation, tuning and tolerance.

R Meldrum Robertson1, Tomas G A Money

  • 1Department of Biology, Queen's University, Kingston, Ontario K7L 3N6, Canada. robertrm@queensu.ca

Current Opinion in Neurobiology
|February 14, 2012
PubMed
Summary
This summary is machine-generated.

Neuronal circuit output rate generally increases with temperature, responding exponentially for slow circuits and linearly for fast ones. Prior temperature exposure enhances resilience through phenotypic plasticity.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Biophysics

Background:

  • Temperature significantly impacts neuronal circuit function at the subcellular level.
  • Predicting the net effect of temperature on neuronal output is complex due to diverse subcellular influences.

Purpose of the Study:

  • To elucidate the relationship between temperature and neuronal circuit output rates.
  • To investigate the differing temperature response patterns (exponential vs. linear) in neuronal circuits.
  • To understand the mechanisms of temperature compensation and failure in neuronal circuits.

Main Methods:

  • Analysis of neuronal circuit output rates across varying temperatures.
  • Characterization of temperature coefficients (Q(10) values) for different circuit types.
  • Examination of ion homeostasis and phenotypic plasticity in response to thermal stress.

Main Results:

  • Neuronal circuit output generally increases with temperature, either exponentially (slow circuits, high Q(10)) or linearly (fast circuits, low temperature coefficients).
  • Opposing processes with similar temperature coefficients can compensate for certain output attributes.
  • At thermal extremes, uncompensated differences in temperature coefficients lead to circuit failure, often involving ion homeostasis disruption.

Conclusions:

  • Neuronal circuit responses to temperature vary based on output speed, exhibiting distinct exponential or linear patterns.
  • Phenotypic plasticity, activated by prior thermal stress, enhances neuronal circuit resilience and recovery.
  • Understanding these temperature-dependent dynamics is crucial for predicting neuronal function and dysfunction.