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Published on: May 30, 2018
Postural and ambulatory changes in regional flow and skin perfusion
1The Rane Center, 1020 River Oaks Dr. #420, Flowood, MS 39232, USA. rajumd@earthlink.net
Summary
Orthostatic changes cause significant deoxygenation in the lower body due to intense vasoconstriction. This previously underestimated mechanism may explain dysvascular syndromes with orthostatic features.
Area of Science:
- Physiology
- Vascular Biology
- Biomedical Engineering
Background:
- Previous studies on orthostatic changes in cutaneous micro-perfusion yielded conflicting results.
- Legacy equipment likely contributed to imprecision in earlier research.
Purpose of the Study:
- To investigate orthostatic changes in micro-perfusion using advanced non-touch technology.
- To quantify regional variations in skin nutrient flow and vascular response.
Main Methods:
- Measured postural flow changes in femoral and carotid vessels using duplex equipment.
- Utilized Hyperspectral imager (OxyVu-2™) for non-contact measurement of skin nutrient flow.
- Studied healthy adults to establish baseline physiological responses.
Main Results:
- Observed regional variations in cutaneous capillary density, with lower density in the abdomen.
- Detected profound lower body cutaneous deoxygenation (approx. 40% reduction) in the erect posture.
- Found preserved quantitative regional flow with increased pulse rate despite decreased femoral vessel velocity.
Conclusions:
- Identified intense orthostatic vasoconstriction and cutaneous deoxygenation in the lower limbs, previously underestimated.
- This potent mechanism is potentially relevant for understanding dysvascular syndromes, especially those with orthostatic symptoms.
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