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Updated: May 25, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
The three dimensions of functional T-cell tolerance: from research to practice
Christian Hünefeld1, Markus Mezger, Michael Röcken
1Department of Dermatology, Eberhard-Karls-University, Tübingen, Germany.
Abstract:
In this issue, Paek et al. describe two phenomena. First, they show that intermediate concentrations of a "transgenic" autoantigen may cause a lichen planus-like autoimmune disease. Second, and more importantly, they show that high doses of peptide antigen suppress the expression of the T-cell receptor and coreceptors, particularly CD8, and that this suppression improves this T-cell-mediated, destructive inflammatory skin disease that is similar to erosive lichen planus.
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