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Updated: May 25, 2026

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Published on: March 31, 2015
Realm of revertant mosaicism expanding
Marcel F Jonkman1, Anna M G Pasmooij
1Department of Dermatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. m.f.jonkman@umcg.nl
Abstract:
In this issue, Lai-Cheong et al. report a patient with Kindler syndrome who showed revertant mosaicism: a patch of normal-looking skin attributable to a reverse mutation. The molecular basis of the reverted patch appeared to be the deletion of a duplicated cytosine, thus restoring the reading frame of FERMT1 transcripts. This finding further pushes the frontier of revertant mosaicism, a phenomenon of spontaneous gene repair, which can be seen with the naked eye in skin.
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