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Related Concept Videos

One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...

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Determination of Continuity Index Values in Atrial Fibrillation Ablation with Proactive Esophageal Cooling
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Intraventricular cooling during CSF infusion studies.

Melanie Schmitt1, Regina Eymann, Sebastian Antes

  • 1Department of Neurosurgery, Saarland University, Homburg, Germany. m.schmitt@uniklinikum-saarland.de

Acta Neurochirurgica. Supplement
|February 14, 2012
PubMed
Summary

Ventricular infusion studies in hydrocephalus patients revealed that increased intracranial pressure (ICP) correlated with decreased brain temperature and stable or increased oxygenation. This suggests ICP-controlled cooling may offer neuroprotection.

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Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Published on: September 1, 2016

Area of Science:

  • Neurosurgery
  • Neurology
  • Intensive Care Medicine

Background:

  • Idiopathic normal pressure hydrocephalus (iNPH), benign intracranial hypertension (BIH), and occlusive hydrocephalus (HOC) require accurate diagnosis for shunt indication.
  • Elevated intracranial pressure (ICP) poses risks to vulnerable brain tissue, necessitating careful monitoring during diagnostic procedures.

Purpose of the Study:

  • To investigate cerebral oxygenation (O2) and temperature changes during ventricular infusion tests in patients with suspected hydrocephalus.
  • To evaluate the correlation between ICP, brain tissue oxygenation, and temperature.
  • To explore the potential of ICP-controlled local cooling for brain protection.

Main Methods:

  • Ventricular infusion studies were conducted on 33 patients with suspected iNPH, BIH, or HOC.
  • Intracranial pressure (ICP) was monitored using ventricle catheters with an ICP tip sensor.
  • Brain tissue oxygenation (pO2) and temperature were measured using intraparenchymal Raumedic PTO probes.

Main Results:

  • In 65% of patients (15/23), pO2 increased (average 140%) while brain temperature decreased (0.2-4.5°C) during infusion.
  • Stable pO2 was observed in six patients; cerebral deoxygenation occurred in only two.
  • Cerebral oxygenation and temperature showed an inverse correlation, likely due to reduced cerebral metabolism from local cooling.

Conclusions:

  • Ventricular infusion tests reveal an inverse relationship between ICP, brain temperature, and oxygenation.
  • ICP-controlled local cooling, potentially mediated by basal arteries, may represent a novel neuroprotective strategy.
  • Further research into ICP-controlled cooling for brain protection in conditions like ICP crises is warranted.