Diagnostic accuracy of global myocardial deformation indexes in coronary artery disease: a velocity vector imaging

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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

Gabriel Valocik1, Ivana Valocikova, Peter Mitro

  • 1Department of Cardiology, East Slovakian Institute of Cardiovascular Disease and Safarik University, Kosice, Slovakia. gabriel.valocik@upjs.sk

The International Journal of Cardiovascular Imaging
|February 14, 2012
PubMed

Insights

Mean radial strain rate (MRSR) effectively predicts multivessel coronary artery disease. This cardiac imaging biomarker demonstrated superior diagnostic accuracy compared to traditional left ventricular function measures.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Diagnostic Accuracy

Background:

  • Multivessel coronary artery disease (MVD) poses significant risks.
  • Accurate non-invasive diagnostic tools for MVD are crucial.
  • Left ventricular deformation analysis offers potential for improved diagnostics.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of left ventricular global longitudinal strain and strain rate (GLS, GLSR) and mean radial strain and strain rate (MRS, MRSR) in predicting MVD.
  • To compare the predictive performance of these deformation parameters against traditional measures like left ventricular ejection fraction (LVEF) and wall motion score index (WMSI).

Main Methods:

  • Speckle-tracking based velocity vector imaging was used to analyze left ventricular deformation in 113 patients undergoing coronary angiography.
  • GLS, GLSR, MRS, and MRSR were calculated from strain and strain rate curves.
  • Patients were categorized into 0-vessel disease (0VD), single-vessel disease (1VD), double-vessel disease (2VD), and triple-vessel disease (3VD) subgroups.

Main Results:

  • All deformation indexes were significantly reduced in patients with 3VD compared to those without significant coronary artery disease.
  • Mean radial strain rate (MRSR) emerged as the strongest predictor of multivessel disease.
  • Receiver-operating characteristic (ROC) curve analysis indicated that MRSR possessed the highest diagnostic accuracy, outperforming LVEF and WMSI.

Conclusions:

  • Global left ventricular deformation indexes, particularly MRSR, demonstrate good diagnostic accuracy in identifying multivessel coronary artery disease.
  • MRSR shows promise as a superior biomarker for detecting triple-vessel disease compared to conventional global and regional left ventricular function assessments.

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