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Neoadjuvant Cis-DDP in esophageal cancers: an experience at a regional cancer centre, India
S K Murthy1, P S Prabhakaran, M Chandrashekar
1Department of Surgery, Kidwai Memorial Institute of Oncology, Bangalore, India.
Abstract:
We are analysing the results of 80 patients who underwent surgery during 1983-84 for esophageal cancer. Forty patients who received pre-operative single agent Cis-DDP were grouped under "A" and 40 patients who went for surgery directly were grouped under "B". Twenty-two patients (55%) of Group A showed tumor necrosis. Both groups underwent resection and hand-sewn anastamosis of the esophagus. There were 10 post-operative deaths among 80 resected cases, 9 of them being from anastomatic leak. Cis-DDP has induced negligible side effects. A comparatively high survival rate during early years in patients who responded to Cis-DDP suggests that neoadjuvant chemotherapy might be of value.