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Published on: June 18, 2014
Electrospun composite scaffolds containing poly(octanediol-co-citrate) for cardiac tissue engineering
Molamma P Prabhakaran1, A Sreekumaran Nair, Dan Kai
1Healthcare and Energy Materials Laboratory, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore 117576. nnimpp@nus.edu.sg
This study developed a biocompatible nanofibrous scaffold from poly(1,8-octanediol-co-citrate) [POC] and poly(L-lactic acid)-co-poly-(3-caprolactone) [PLCL] for cardiac tissue engineering. The optimized POC/PLCL scaffold shows mechanical properties similar to native heart tissue and supports cardiac cell growth.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Cardiac tissue engineering requires scaffolds that mimic native heart tissue's mechanical and biological properties.
- Developing biocompatible and elastomeric materials is crucial for successful cardiac regeneration.
Purpose of the Study:
- To create and characterize a novel electrospun nanofibrous scaffold from poly(1,8-octanediol-co-citrate) [POC] and poly(L-lactic acid)-co-poly-(3-caprolactone) [PLCL] for cardiac tissue engineering.
- To evaluate the mechanical properties, degradation behavior, and cellular response of POC/PLCL composite scaffolds.
Main Methods:
- Electrospinning of POC/PLCL blends.
- Characterization using Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), and tensile testing.
- Assessment of cardiac myoblast cell proliferation and morphology.
Main Results:
- Scaffold mechanical properties and degradation can be tuned by adjusting the POC concentration.
- The POC/PLCL4060 scaffold exhibited tensile strength and Young's Modulus comparable to native cardiac tissue.
- Increased POC concentration enhanced cardiac myoblast proliferation and demonstrated scaffold biocompatibility.
Conclusions:
- Electrospun POC/PLCL nanofibrous scaffolds are promising for cardiac tissue engineering.
- The POC/PLCL4060 composite provides suitable mechanical cues for cardiac muscle cell regeneration.
- Tuning the POC concentration allows for optimization of scaffold properties for cardiac applications.
