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Microalbuminuria is an independent prognostic marker in patients with chronic heart failure

Humberto Villacorta1, Paula de Vilhena Ferradaes, Evandro Tinoco Mesquita

  • 1Curso de Pós-Graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, Brazil. hvillacorta@cardiol.br

Arquivos Brasileiros De Cardiologia
|February 14, 2012
PubMed
Abstract

Insights

Microalbuminuria is an independent prognostic marker in patients with chronic heart failure (HF). Patients with microalbuminuria have a higher risk of cardiovascular events and mortality, indicating its clinical significance.

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Research

Background:

  • Microalbuminuria is a known risk factor for cardiovascular and renal diseases.
  • Its prognostic value in patients with established heart failure (HF) is not well understood.

Purpose of the Study:

  • To evaluate microalbuminuria as a prognostic marker in patients with chronic heart failure (HF).
  • To assess its role in patients receiving standard HF medication.

Main Methods:

  • Prospective study of 92 patients with chronic HF (mean age 63.7 years, 40.7% male).
  • Urinary albumin concentration (UAC) measured in spot urine samples.
  • Endpoint: HF hospitalization, ED visit for HF, or cardiovascular death; mean follow-up 11 months.

Main Results:

  • 41.3% of patients had microalbuminuria; none had overt albuminuria.
  • Microalbuminuria was associated with lower left ventricular ejection fraction (LVEF) (p=0.08).
  • Higher UAC correlated with increased risk of cardiac events (p<0.0001) and lower event-free survival (p<0.0001).

Conclusions:

  • Microalbuminuria is an independent predictor of adverse outcomes in chronic HF.
  • Microalbuminuria may indicate a trend towards lower LVEF in HF patients.

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