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Updated: May 25, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Structure elucidation and NMR assignments of new spirosolane alkaloids from Solanum campaniforme
Maria Conceição M Torres1, José Gustavo L Almeida, Raimundo Braz-Filho
1Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 12.200, Fortaleza-CE, 60.021-970, Brazil.
Abstract:
From the leaves of Solanum campaniforme, two new spirosolane alkaloids β-acetoxyl-(25S)-22βN-spirosol-4-en-3-one (1) and β-hydroxyl-(25S)-22βN-spirosol-4-en-3-one (4) were isolated along with two other known alkaloids of the same class (25S)-22βN-spirosol-1,4-dien-3-one (2) and (25S)-22βN-spirosol-4-en-3-one (3), which are reported for the first time as natural products. The structures of all alkaloids were established after an extensive analysis by 1D and 2D NMR spectroscopy (COSY, HSQC, HMBC and NOESY) as well as HRESIMS.
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