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Updated: May 25, 2026
11:39
Identification of Functional Protein Regions Through Chimeric Protein Construction
Published on: January 8, 2019
In silico design of functional DNA constructs.
Alan Villalobos1, Mark Welch, Jeremy Minshull
1DNA2.0, Inc., Menlo Park, CA, USA.
Methods in Molecular Biology (Clifton, N.J.)
|February 14, 2012
Summary
Synthetic biology enables novel functions by combining genetic elements. Gene Designer software facilitates the creation and optimization of these genetic constructs for research and engineering applications.
Area of Science:
- Synthetic Biology
- Molecular Biology
- Bioengineering
Background:
- Synthetic biology aims to engineer novel biological functions through the assembly of genetic elements.
- De novo gene synthesis offers a cost-effective approach to construct custom genetic sequences, overcoming limitations of natural ones.
- The increasing availability of characterized genetic parts necessitates efficient tools for their assembly into functional systems.
Purpose of the Study:
- To introduce Gene Designer, a software tool for managing and assembling genetic elements.
- To provide capabilities for simulating molecular cloning and optimizing protein-coding sequences.
- To offer a comprehensive solution for designing functional genetic constructs.
Main Methods:
- Gene Designer software facilitates the management and recombination of genetic elements.
- The software includes tools for simulating molecular cloning procedures.
- It offers features for engineering and optimizing protein-coding sequences.
Main Results:
- Gene Designer enables scientists and engineers to readily assemble genetic elements into novel constructs.
- The software supports the simulation of cloning strategies.
- It aids in the optimization of protein-coding sequences for desired functions.
Conclusions:
- Gene Designer provides a complete suite of functions for designing functional genetic constructs.
- The software empowers researchers to create novel genetic assemblies efficiently.
- It supports the advancement of synthetic biology by facilitating the design-build-test cycle.
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