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Updated: May 25, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Pubertal development in ICSI children.

F Belva¹, M Roelants, R Painter

¹Center for Medical Genetics, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, Brussels 1090, Belgium. florence.belva@uzbrussel.be

Human Reproduction (Oxford, England)

|February 14, 2012

Summary

This summary is machine-generated.

Pubertal development in adolescents born after intracytoplasmic sperm injection (ICSI) is largely comparable to spontaneously conceived peers, except for slightly delayed breast development in females. Long-term studies are needed to confirm timely progression through puberty.

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Human Egg Maturity Assessment and Its Clinical Application

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Published on: August 19, 2019

Area of Science:

Reproductive Medicine
Pediatric Endocrinology
Human Development

Background:

Information on pubertal development in ICSI-conceived adolescents is limited as the first cohort reaches young adulthood.
This study investigates pubertal development at age 14 in ICSI-conceived teenagers compared to spontaneously conceived controls.

Purpose of the Study:

To characterize and compare the pubertal development of ICSI-conceived teenagers with spontaneously conceived peers at age 14.
To identify any differences in Tanner staging and age at menarche between the two groups.

Main Methods:

Longitudinal cohort of 217 ICSI-conceived children and a cross-sectional sample of 223 spontaneously conceived peers.
Assessment of pubertal development using Tanner staging (breast, genital, pubic hair) and age at menarche.
Logistic regression analysis to compare pubertal development between ICSI and SC groups, adjusting for confounders.

Main Results:

Mean age at menarche was similar in ICSI and SC girls (13.1 years).
Breast development at age 14 was less advanced in ICSI females compared to SC females, even after adjustment for confounders (OR 0.5).
Genital and pubic hair development were comparable between ICSI and SC groups for both males and females after adjustment.

Conclusions:

Pubertal milestones like menarche, and genital/pubic hair development in males and females, were comparable between ICSI and SC groups.
A notable finding was less advanced breast development in ICSI females.
Long-term follow-up is necessary to confirm timely progression through all pubertal stages in ICSI-conceived individuals.