Related Experiment Video
Updated: May 25, 2026
05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
Generalized lichen nitidus in Russell-Silver syndrome
Chie Kanai1, Mika Terao, Atsushi Tanemura
1Department of Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Pediatric Dermatology
|February 15, 2012
Summary
Generalized lichen nitidus, a rare skin condition, was observed in a patient with Russell-Silver syndrome. This case highlights a potential link between this rare disease and a specific genetic disorder.
Area of Science:
- Dermatology
- Genetics
- Rare Diseases
Background:
- Generalized lichen nitidus is an uncommon dermatological condition.
- Associations between lichen nitidus and genetic disorders are infrequently reported.
- Russell-Silver syndrome is a rare genetic disorder characterized by intrauterine growth restriction and distinctive facial features.
Observation:
- This report details a unique case of generalized lichen nitidus.
- The patient presented with symptoms of Russell-Silver syndrome.
- The co-occurrence of these two conditions is noteworthy.
Findings:
- The study documents a case of generalized lichen nitidus in a patient diagnosed with Russell-Silver syndrome.
- This finding contributes to the limited literature on lichen nitidus associated with genetic conditions.
- The case provides clinical evidence for a potential association.
Implications:
- This case may prompt further investigation into the genetic underpinnings of generalized lichen nitidus.
- Understanding this association could aid in the diagnosis and management of patients with Russell-Silver syndrome.
- Further research is warranted to explore the relationship between lichen nitidus and genetic disorders.
More Related Videos
Related Concept Videos
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:22Lysosomal Hydrolases
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
01:22Myasthenia Gravis ll: Pathophysiology
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...