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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Borderline Personality Disorder01:25

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...

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Updated: May 25, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
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Relationship between suicidality and impulsivity in bipolar I disorder: a diffusion tensor imaging study.

Katie Mahon1, Katherine E Burdick, Jinghui Wu

  • 1Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA.

Bipolar Disorders
|February 15, 2012
PubMed
Summary
This summary is machine-generated.

Individuals with bipolar disorder and a history of suicide attempts show altered orbital frontal white matter integrity and increased impulsivity. This suggests a link between white matter abnormalities and suicidal behaviors in bipolar disorder.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Impulsivity is a key feature of bipolar disorder, potentially contributing to high suicide rates.
  • White matter abnormalities are suspected in bipolar disorder's pathophysiology but their link to impulsivity and suicidality is unclear.

Purpose of the Study:

  • To investigate the relationship between white matter integrity, impulsivity, and a history of suicide attempts in bipolar disorder patients.

Main Methods:

  • Diffusion tensor imaging (DTI) was used to examine white matter in 14 bipolar disorder patients with prior suicide attempts, 15 without, and 15 healthy controls.
  • Clinical assessments measured impulsivity, depression, mania, and anxiety.
  • Tract-Based Spatial Statistics (TBSS) in FSL software processed the DTI data.

Main Results:

  • Bipolar disorder patients with a suicide attempt history exhibited reduced fractional anisotropy (FA) in left orbital frontal white matter compared to those without.
  • Patients with a prior suicide attempt showed higher overall impulsivity.
  • A negative correlation was found between orbital frontal white matter FA and motor impulsivity in patients with a suicide attempt history.

Conclusions:

  • Abnormalities in the orbital frontal white matter may be implicated in the impulsive and suicidal behaviors observed in bipolar disorder.
  • These findings highlight a potential neurobiological substrate for suicidality in bipolar disorder.