Related Experiment Video
Updated: May 25, 2026

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
Published on: September 13, 2018
Transcription as a source of genome instability
Nayun Kim1, Sue Jinks-Robertson
1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Abstract:
Alterations in genome sequence and structure contribute to somatic disease, affect the fitness of subsequent generations and drive evolutionary processes. The crucial roles of highly accurate replication and efficient repair in maintaining overall genome integrity are well-known, but the more localized stability costs that are associated with transcribing DNA into RNA molecules are less appreciated. Here we review the diverse ways in which the essential process of transcription alters the underlying DNA template and thereby modifies the genetic landscape.
Related Concept Videos
Genome Copying Errors
Spontaneous and Induced Mutations
Gene Conversion
Gene Conversion
Proofreading
Proofreading
Errors During Replication are Corrected by the DNA Polymerase Enzyme
