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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
X-linked Traits01:19

X-linked Traits

In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.

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Related Experiment Video

Updated: May 25, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Cellular genomics for complex traits.

Emmanouil T Dermitzakis1

  • 1Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel-Servet, 1211 Geneva, Switzerland. emmanouil.dermitzakis@unige.ch

Nature Reviews. Genetics
|February 15, 2012
PubMed
Summary
This summary is machine-generated.

Cellular phenotyping using large datasets and organismal data analysis offers new insights into genetic and environmental influences on complex traits. This approach promises to transform our understanding of human biology by analyzing cellular models.

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
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In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

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Last Updated: May 25, 2026

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05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

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In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Area of Science:

  • Genomics
  • Systems Biology
  • Human Biology

Background:

  • Large-scale collection and analysis of multilayered cellular data are advancing alongside extensive organismal phenotyping.
  • Cellular resources are increasingly utilized as models for understanding human biology, a process termed 'cellular phenotyping'.
  • This integration holds potential for transforming the study of complex traits.

Purpose of the Study:

  • To discuss the advantages and limitations of in-depth analysis of cellular phenotypes in large cohorts.
  • To assess methodological advancements in cellular phenotyping.
  • To evaluate the resource requirements and future prospects of this emerging approach.

Main Methods:

  • Analysis of multilayered cellular data from large cohorts.
  • Integration of organismal phenotyping data with cellular data.
  • Review of methodological advances and resource needs for cellular phenotyping.

Main Results:

  • Cellular phenotyping provides a powerful approach to link genetic variation with biological processes.
  • This method enhances understanding of genetic and long-term environmental influences on complex traits.
  • The analysis reveals both the potential and the challenges of this new research direction.

Conclusions:

  • Cellular phenotyping in large cohorts is a transformative approach for human biology research.
  • Careful consideration of advantages, caveats, and resource needs is crucial for its successful implementation.
  • Future prospects are significant for unraveling the genetic and environmental underpinnings of complex traits.