Peripheral oxidative stress in relapsing-remitting multiple sclerosis
Related Experiment Video
Updated: May 25, 2026
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Inmaculada Tasset1, Eduardo Agüera, Fernando Sánchez-López
1Departamento de Bioquímica y Biología Molecular, Facultad de Medicina/Instituto Maimónides de Investigación Biomédica de Córdoba/Universidad de Córdoba, Spain.
Objectives:
To evaluate levels of oxidative stress in blood samples in patients with relapsing-remitting MS (RR-MS).
Design And Methods:
Peripheral blood samples were collected from 24 RR-MS patients and 15 healthy controls. Levels of the following were measured: carbonylated proteins, 8-hydroxy-2'deoxyguanosine (8OHdG), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione-S-transferase (GST), myeloperoxidase (MPO), antioxidant gap, total antioxidant capacity (PAO), global oxidative stress (GOS), serum vascular cell adhesion molecule-1 (sVCAM-1) and serum inter-cellular adhesion molecule 1 (sICAM-1).
Results:
Values for carbonylated proteins, 8OHdG, total glutathione, GSH, GSH/GSSG ratio, SOD, GRd and GOS were significantly higher in RR-MS patients than in healthy controls. By contrast, PAO, GSSG, GPx and GST were lower in RR-MS patients.
Conclusion:
Oxidative stress plays a major role in MS, and is observed prior to relapse.
Related Concept Videos
01:19Multiple Sclerosis l: Introduction
01:25Secondary Spinal Cord Injury llI: Pathophysiology