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Peripheral oxidative stress in relapsing-remitting multiple sclerosis
Inmaculada Tasset1, Eduardo Agüera, Fernando Sánchez-López
1Departamento de Bioquímica y Biología Molecular, Facultad de Medicina/Instituto Maimónides de Investigación Biomédica de Córdoba/Universidad de Córdoba, Spain.
Clinical Biochemistry
|February 15, 2012
Summary
Oxidative stress markers are elevated in patients with relapsing-remitting multiple sclerosis (RR-MS), indicating its significant role in the disease, even before relapse.
Area of Science:
- Neuroimmunology
- Biochemistry
- Oxidative Stress Research
Background:
- Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
- Oxidative stress is implicated in the pathogenesis of various neurological disorders.
- Understanding oxidative stress in MS is crucial for developing targeted therapies.
Purpose of the Study:
- To quantify oxidative stress biomarkers in patients with relapsing-remitting MS (RR-MS).
- To compare oxidative stress levels between RR-MS patients and healthy controls.
Main Methods:
- Blood samples were analyzed from 24 RR-MS patients and 15 healthy controls.
- Key oxidative stress markers including carbonylated proteins, 8-hydroxy-2'deoxyguanosine (8OHdG), glutathione (GSH, GSSG), and antioxidant enzymes (SOD, GPx, GRd, GST) were measured.
- Additional markers like myeloperoxidase (MPO), antioxidant gap, total antioxidant capacity (PAO), global oxidative stress (GOS), sVCAM-1, and sICAM-1 were assessed.
Main Results:
- Significantly higher levels of carbonylated proteins, 8OHdG, total glutathione, reduced glutathione (GSH), GSH/GSSG ratio, superoxide dismutase (SOD), glutathione reductase (GRd), and global oxidative stress (GOS) were observed in RR-MS patients.
- Conversely, RR-MS patients exhibited lower levels of total antioxidant capacity (PAO), oxidized glutathione (GSSG), glutathione peroxidase (GPx), and glutathione-S-transferase (GST).
Conclusions:
- Oxidative stress is a significant factor in the pathophysiology of MS.
- Elevated oxidative stress markers are detectable in RR-MS patients, suggesting their involvement prior to clinical relapse.
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