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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

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Related Experiment Video

Updated: May 25, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Psoriasis: issues far more serious than cosmetic.

Guido R Zanni1

  • 1The Consultant Pharmacist, Alexandria, VA, USA.

The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists
|February 15, 2012
PubMed
Summary

Psoriasis, an autoimmune disease, presents varied triggers and comorbidities, impacting mortality. While incurable, treatments manage symptoms, but knowledge gaps persist regarding onset, progression, and comparative effectiveness of therapies.

Area of Science:

  • Immunology
  • Dermatology
  • Public Health

Background:

  • Psoriasis is the most common autoimmune disorder in the US.
  • It is a chronic, relapsing condition influenced by genetic and environmental factors.
  • Psoriasis is an independent risk factor for mortality and associated with numerous comorbidities.

Purpose of the Study:

  • To provide a comprehensive overview of psoriasis.
  • To highlight the association of psoriasis with various comorbidities.
  • To discuss current management strategies and identify knowledge gaps.

Main Methods:

  • Literature review of psoriasis epidemiology, pathophysiology, and treatment.
  • Analysis of comorbidities associated with psoriasis.
  • Summary of current therapeutic options and research needs.

Related Experiment Videos

Last Updated: May 25, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Main Results:

  • Psoriasis is linked to cardiovascular disease, diabetes, depression, obesity, and more.
  • Management options include topical treatments, phototherapy, systemic agents, and biologics.
  • Combination therapy is often necessary for moderate-to-severe cases, requiring medication adherence.

Conclusions:

  • Psoriasis is a significant health concern with broad systemic implications.
  • Effective management requires adherence to treatment regimens.
  • Further research is needed on disease onset, progression, and comparative treatment effectiveness.