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Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
Published on: January 22, 2018
Subretinal fibrosis in Stargardt's disease: case report
Alexandre Achille Grandinetti1, Ezequiel Portella, Jayme Arana
1Setor de Retina e Vítreo, Hospital das Clínicas, Universidade Federal do Paraná - UFPR - Curitiba (PR), Brazil. alexandregrandinetti@gmail.com
Abstract:
The authors describe the clinical characteristics of a 14-year-old female patient with ophthalmoscopic and angiographic aspects of Stargardt's disease in both eyes who developed subretinal fibrosis and localized retinal pigment epithelial hyperplasia in the posterior pole of the right eye 6 months after a mild blunt trauma to the right globe. The left fundus remains with the typical presentation of Stargardt's disease. Our findings support the theory that ocular trauma occurring in patients with Stargardt's disease can precipitate a sequence of events leading to the development of subretinal fibrosis and significant visual loss.

