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Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture
Published on: January 11, 2016
Bottom-up approach to build osteon-like structure by cell-laden photocrosslinkable hydrogel
Yicong Zuo1, Wenqian Xiao, Xiaoqin Chen
1National Engineering Research Center for Biomaterials, Sichuan University, 610064, Chengdu, China.
Chemical Communications (Cambridge, England)
|February 15, 2012
Abstract:
Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approach employing the GelMA hydrogel with a higher biocompatibility was more favorable for building biomimetic osteon.
