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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: May 25, 2026

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

Methods for motion correction evaluation using 18F-FDG human brain scans on a high-resolution PET scanner.

Sune H Keller1, Merence Sibomana, Oline V Olesen

  • 1Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, University Hospital, Copenhagen, Denmark. sune@pet.rh.dk

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|February 15, 2012
PubMed
Summary

Quality control methods for motion correction in PET scans were developed. These methods effectively evaluate external motion tracking, though automated image registration showed better performance for major motion.

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Image Processing

Background:

  • Patient motion during PET scans significantly impacts kinetic analysis and image resolution.
  • Misaligned transmission data for attenuation and scatter correction can introduce quantification bias in emission images.

Purpose of the Study:

  • Develop and evaluate quality control (QC) methods for motion correction (MC) in human PET scans.
  • Assess MC procedures utilizing external motion tracking (EMT) via an optical system.

Main Methods:

  • Selected (18)F-FDG PET scans with minor (<2 mm) and major (>4 mm) motion, identified by optical motion tracking.
  • Applied automated image registration (AIR) and EMT for motion correction on time-framed emission data.
  • Evaluated MC performance using three QC methods: gray/white matter ratio (GM/WM), mutual information, and cross-correlation.

Main Results:

  • The three QC methods yielded consistent results, aligning with visual inspection.
  • Pre-MC scans with major motion showed significant variations in QC measures; minor motion scans had limited variations.
  • Post-MC, AIR significantly reduced variations and improved measures, while EMT MC performed less effectively.

Conclusions:

  • The developed QC methods are reliable for evaluating tracer-independent, external-tracking motion correction techniques in human brain PET.
  • Automated image registration demonstrated superior performance in motion correction for significant patient movement compared to EMT.