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The C. elegans Excretory Canal as a Model for Intracellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis in a Single Cell: labeling by GFP-fusions, RNAi Interaction Screen and Imaging
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The C. elegans Excretory Canal as a Model for Intracellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis in a Single Cell: labeling by GFP-fusions, RNAi Interaction Screen and Imaging

Published on: October 3, 2017

Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion.

Anna K Townley1, Katy Schmidt, Lorna Hodgson

  • 1Cell Biology Laboratories, School of Biochemistry, Medical Sciences Building, University of Bristol, University Walk, Bristol, BS8 1TD, UK.

Journal of Cell Science
|February 15, 2012
PubMed
Summary

Coat complex II (COPII) vesicle formation, driven by Sec13, is crucial for epithelial morphogenesis. Depleting Sec13 disrupts gut epithelium organization and cell polarity, impacting tissue development.

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