Related Experiment Video
Updated: May 24, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Angioedema in a 47-year-old woman with hypocomplementemic urticarial vasculitis syndrome
Julie M Jones1, Keith A Reich, Deena G Raval
1Department of Internal Medicine, Midwestern University/Chicago College of Osteopathic Medicine, Downers Grove, Illinois, USA. julie.jones@mwumail.midwestern.edu
Abstract:
Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a type III hypersensitivity reaction characterized by urticaria with persistent acquired hypocomplementemia. Although HUVS is uncommon, it is important for physicians to be familiar with this disease, as the initial presentation is often life-threatening angioedema. The author reports the case of a 47-year-old white woman with a history of HUVS. She presented to an outpatient clinic complaining of a rash and difficulty swallowing. Urticaria and angioedema were diagnosed. The patient was given epinephrine in the clinic and then transferred to the hospital. Laboratory testing confirmed urticaria, and the patient was given intravenous methylprednisolone sodium succinate and an additional dose of epinephrine. After 1 week, the patient's angioedema improved.
Related Concept Videos
Hypersensitivity Reactions: Immune-Complex Reactions
Endocarditis II: Clinical Features of Infective Endocarditis
Nephrotic Syndrome II : Assessment and Medical Management
Nephrotic Syndrome I : Introduction
Cytotoxic Edema: Pathophysiology
Assessment of the Cardiovascular System III: Palpation
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...