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Heterogeneous DNA methylation as an early marker of cancer

Moshe Szyf1

  • 1Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada. moshe.szyf@mcgill.ca

Epigenomics
|February 16, 2012
PubMed
Abstract

No abstract available in PubMed .

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...