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Acute hyperfibrinogenemia impairs cochlear blood flow and hearing function in guinea pigs in vivo
Fritz Ihler1, Sebastian Strieth, Nicos Pieri
1Department of Otorhinolaryngology, Head and Neck Surgery, University of Göttingen Hospital, Robert-Koch-Strasse 40, Göttingen, Germany.
Objective:
Impairment of microcirculation is a possible cause of sudden sensorineural hearing loss (SSNHL). Fibrinogen is known as a risk factor for both microvascular dysfunction and SSNHL. Therefore, the aim of this study was to investigate the effect of elevated serum levels of fibrinogen on cochlear blood flow and hearing function in vivo.
Design:
One group of guinea pigs received two consecutive injections of 100 mg fibrinogen while a control group received equimolar doses of albumin. Measurements of cochlear microcirculation by intravital microscopy and of hearing thresholds by auditory brainstem response (ABR) recordings were carried out before, after first and after second injection.
Study Sample:
Ten healthy guinea pigs were randomly assigned to a treatment group or a control group of five animals each.
Results:
Serum fibrinogen levels were elevated after the first and second injections of fibrinogen compared to basal values and control group respectively. Increasing levels of fibrinogen were paralleled by decreasing cochlear blood flow as well as increasing hearing thresholds. Hearing threshold correlated negatively with cochlear blood flow.
Conclusions:
The effect of microcirculatory impairment on hearing function could be explained by a malfunction of the cochlear amplifier. Further investigation is needed to quantify cochlear potentials under elevated serum fibrinogen levels.
