[Relationship between computed tomography perfusion imaging and prognosis in hyperacute cerebral infarction]

Area of Science:

• Neurology
• Radiology
• Medical Imaging

Background:

• Acute cerebral infarction requires rapid and accurate diagnosis.
• Computed Tomography Perfusion (CTP) is a neuroimaging technique used to assess cerebral blood flow.
• Understanding CTP's role in hyperacute stroke is crucial for timely intervention.

Purpose of the Study:

• To evaluate the diagnostic value of CTP in hyperacute cerebral infarction.
• To examine the relationship between symptom onset to examination time and CTP parameters.
• To correlate CTP findings with clinical outcomes and stroke severity.

Main Methods:

• 75 patients with acute cerebral infarction underwent non-contrast CT and CTP within 8 hours of symptom onset.
• Neurological function, daily living activities, and disability were assessed using NIHSS, BI, and mRS scores.
• Statistical analysis was performed to correlate CTP parameters with time to imaging and clinical outcomes.

Main Results:

• CTP parameters in the ischemic region showed no correlation with the time from symptom onset to examination.
• Cerebral Blood Flow (CBF) in the ischemic region significantly correlated with NIHSS scores at multiple time points.
• Cerebral Blood Volume (CBV) and Time-to-Peak (TTP) correlated with clinical outcome prediction indices.

Conclusions:

• The time elapsed since symptom onset does not accurately reflect the extent of cerebral infarction.
• CTP is valuable for assessing the severity and prognosis of acute cerebral infarction.
• The area of abnormal perfusion on CTP is the most sensitive parameter for evaluating stroke.