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Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

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Updated: May 24, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

Mir-33 regulates cell proliferation and cell cycle progression.

Daniel Cirera-Salinas1, Montse Pauta, Ryan M Allen

  • 1Department of Medicine, Leon H. Charney Division of Cardiology and Cell Biology and Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY, USA.

Cell Cycle (Georgetown, Tex.)
|February 16, 2012
PubMed
Summary

MicroRNAs (miRNAs) regulate cell proliferation by inhibiting cell cycle genes. Inhibiting miR-33 enhances liver regeneration, suggesting its role in liver repair.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are key posttranscriptional regulators of gene expression.
  • hsa-miR-33a and hsa-miR-33b, located within Srebp genes, are known regulators of cholesterol and fatty acid metabolism.
  • Emerging evidence suggests miRNAs play roles beyond metabolic regulation.

Purpose of the Study:

  • To investigate the role of hsa-miR-33 family members in cell cycle regulation and proliferation.
  • To determine the impact of miR-33 on liver regeneration.
  • To explore the therapeutic potential of modulating miR-33 activity.

Main Methods:

  • Investigated miR-33's effect on cell cycle genes (CDK6, CCND1) using cell lines (Huh7, A549).
  • Induced G1 cell cycle arrest via miR-33 overexpression.
  • Utilized 2'F/MOE-modified antisense oligonucleotides to inhibit miR-33 in a mouse model of partial hepatectomy (PH).

Main Results:

  • miR-33 was found to inhibit the expression of cyclin-dependent kinase 6 (CDK6) and cyclin D1 (CCND1).
  • Overexpression of miR-33 led to a significant G1 cell cycle arrest in tested cell lines.
  • Inhibition of miR-33 expression significantly improved liver regeneration following partial hepatectomy in mice.

Conclusions:

  • The miR-33 family plays a crucial role in regulating cell proliferation and cell cycle progression.
  • Modulating miR-33 activity, particularly through inhibition, shows promise for enhancing liver regeneration.
  • The Srebp/miR-33 locus may cooperate to control cell proliferation and holds relevance for human liver regeneration.