Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacokinetics in acute illness.

L B Jellett1, V J Heazlewood

  • 1Royal Brisbane Hospital, Herston, Qld.

The Medical Journal of Australia
|November 5, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Successful use of dexamethasone when prednisolone is not tolerated.

Obstetric medicine·2016
Same author

Venous thromboembolism prophylaxis audit in two Queensland hospitals.

Internal medicine journal·2012
Same author

Survival.

Annals of internal medicine·1997
Same author

Altered pharmacokinetics of tricyclic antidepressants in burns.

The Australian and New Zealand journal of psychiatry·1991
Same author

A review of the management of oral drug overdose in the Accident and Emergency Department of the Royal Brisbane Hospital.

Archives of emergency medicine·1991
Same author

Frontal sinus osteoma with complicating intracranial aerocele.

The Australian and New Zealand journal of surgery·1990

Critically ill patients experience organ dysfunction and altered drug pharmacokinetics. Effective drug treatment requires understanding these changes and adapting management plans based on patient response.

Area of Science:

  • Pharmacology
  • Critical Care Medicine
  • Clinical Pharmacy

Background:

  • Severe illness causes organ dysfunction, impacting drug absorption, distribution, metabolism, and excretion.
  • Patients across the age spectrum, from premature infants to the elderly, face complex drug management challenges in critical illness.

Purpose of the Study:

  • To highlight the importance of understanding pharmacokinetic principles in critically ill patients.
  • To emphasize the need for flexible management plans and close patient monitoring in critical care settings.

Main Methods:

  • Review of established principles of drug pharmacokinetics in the context of critical illness.
  • Discussion of age-related physiological changes affecting drug disposition and action.

Related Experiment Videos

Main Results:

  • Organ dysfunction significantly alters drug pharmacokinetics (absorption, distribution, metabolism, excretion).
  • Age extremes (premature infants, octogenarians) present unique pharmacokinetic challenges.
  • A flexible, individualized approach to drug therapy is essential.

Conclusions:

  • Clinicians must possess a strong understanding of pharmacokinetics to optimize drug therapy in critical illness.
  • Careful patient observation and adaptation of treatment regimens are crucial for managing drug effects in severe illness.