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Related Experiment Video

Updated: May 24, 2026

Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro

Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro

Published on: June 20, 2018

Tongue histoplasmosis mimicking malignancy.

Ajay Garg¹, Raman Wadhera, S P Gulati

¹Department of Otorhinolaryngology, Pathology, PT. BDS, PGIMS, Rohtak, India.

The Journal of the Association of Physicians of India

|February 17, 2012

Summary

A 42-year-old male experienced difficulty swallowing due to a tongue ulcer. Histopathology revealed histoplasmosis, a fungal infection, which successfully treated with itraconazole.

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Area of Science:

Oral Medicine
Infectious Diseases
Mycology

Background:

Progressive dysphagia is a concerning symptom requiring thorough investigation.
Oral ulcers can present diagnostic challenges, sometimes mimicking malignancy.

Observation:

A 42-year-old male presented with a 6-month history of worsening difficulty swallowing.
Oral examination identified an ulcer on the right dorsum of the tongue.

Findings:

The tongue ulcer was initially suspected to be malignant.
Histopathological examination of an incisional biopsy confirmed the diagnosis of histoplasmosis.
The patient demonstrated a positive clinical response to oral itraconazole therapy.

Implications:

This case highlights the importance of considering uncommon infections in the differential diagnosis of oral lesions.
Early and accurate diagnosis of histoplasmosis is crucial for effective management and preventing complications.
Antifungal therapy, such as itraconazole, is effective in treating oral histoplasmosis.