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Published on: July 12, 2021
Febrile seizures: risks, evaluation, and prognosis
Reese C Graves1, Karen Oehler, Leslie E Tingle
1Baylor Family Medicine Residency Program, Garland, TX 75042, USA. reese.graves@baylorhealth.edu
Insights
Febrile seizures are common in young children. Evaluation focuses on seizure complexity and fever source, with routine tests generally not recommended for uncomplicated cases.
Area of Science:
- Pediatrics
- Neurology
Background:
- Febrile seizures are common in children under five.
- Risk factors for febrile seizures have been identified.
Purpose of the Study:
- To outline current recommendations for evaluating and managing febrile seizures.
- To inform about the risk of recurrence and long-term effects.
Main Methods:
- Clinical evaluation to identify complex seizure features and fever source.
- Guidelines on the judicious use of diagnostic tests like blood work, neuroimaging, and EEG.
- Management strategies for febrile status epilepticus.
Main Results:
- Routine blood tests, neuroimaging, and EEG are not recommended for uncomplicated febrile seizures.
- Lumbar puncture is not recommended for uncomplicated febrile seizures.
- Recurrence risk ranges from 15-70% within two years, influenced by age and fever characteristics.
Conclusions:
- Physicians should reassure parents about the low risk of long-term adverse effects.
- Recurrence risk is higher in infants and those with specific clinical features.
- Preventive medication is not recommended for recurrent febrile seizures.
Abstract:
Febrile seizures are common in the first five years of life, and many factors that increase seizure risk have been identified. Initial evaluation should determine whether features of a complex seizure are present and identify the source of fever. Routine blood tests, neuroimaging, and electroencephalography are not recommended, and lumbar puncture is no longer recommended in patients with uncomplicated febrile seizures. In the unusual case of febrile status epilepticus, intravenous lorazepam and buccal midazolam are first-line agents. After an initial febrile seizure, physicians should reassure parents about the low risk of long-term effects, including neurologic sequelae, epilepsy, and death. However, there is a 15 to 70 percent risk of recurrence in the first two years after an initial febrile seizure. This risk is increased in patients younger than 18 months and those with a lower fever, short duration of fever before seizure onset, or a family history of febrile seizures. Continuous or intermittent antiepileptic or antipyretic medication is not recommended for the prevention of recurrent febrile seizures.
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