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Updated: May 24, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Prevalence and risk factors for chronic kidney disease in patients with coronary artery disease
Yu-Shi Bao1, Shi-Ping Na, Xi-Bei Jia
1Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China.
Insights
Chronic kidney disease (CKD) is prevalent in patients with coronary artery disease (CAD). Key risk factors include hypertension, diabetes mellitus, and elevated serum uric acid, highlighting the need for targeted interventions in this high-risk population.
Area of Science:
- Nephrology
- Cardiology
- Public Health
Background:
- Chronic kidney disease (CKD) presents a significant global health challenge.
- Coronary artery disease (CAD) patients often share traditional CKD risk factors.
Purpose of the Study:
- To investigate the prevalence and characteristics of CKD risk factors within a CAD patient cohort.
- To identify specific risk factors associated with reduced estimated glomerular filtration rate (eGFR) in CAD patients.
Main Methods:
- Evaluated renal function in 527 patients diagnosed with CAD.
- Defined CKD based on eGFR, excluding proteinuria from the diagnostic criteria.
Main Results:
- Univariate analysis identified age, smoking, diabetes mellitus, hypertension, and systolic blood pressure as significant risk factors for CKD in CAD patients.
- Multivariable analysis revealed hypertension, diabetes mellitus, and serum uric acid as independent predictors of reduced eGFR.
- A higher prevalence of both hypertension and diabetes mellitus was observed in patients with CKD stages 3-4.
Conclusions:
- CKD is highly prevalent among individuals with CAD, underscoring a significant overlap in risk.
- Hypertension, diabetes mellitus, and elevated serum uric acid are critical independent risk factors for reduced kidney function in this population.
- Patients with CAD should be considered at high risk for developing CKD, necessitating proactive screening and management strategies.
Objectives:
Chronic renal disease (CKD) is recognized as a worldwide public health problem. Traditional risk factors for CKD are also present in coronary artery disease (CAD). The purpose of this study is to examine the prevalence and characteristics of risk factors for CKD in the population with CAD.
Methods:
Renal function was evaluated in 527 patients with CAD in order to assess characteristics of the incidence, risk factors for CKD in the population with CAD. In the present study in order to concentrate on evaluation for eGFR of the patients with CAD proteinuria is not included in the definition of CKD.
Results:
Univariate analysis demonstrated that the major risk factors associated with CKD in the patients with CAD were age (P ≤ 0.001), smoking (P = 0.016), diabetes mellitus (P = 0.021), hypertension (P ≤ 0.001), and systolic blood pressure (P = 0.004). The percentages of patients with both hypertension and diabetes mellitus were significantly greater in the CKD3-4 group (P < 0.001). The results of multivariable analysis showed that hypertension (OR 1.925, 95% CI 1.196-3.098, P = 0.007), diabetes mellitus (OR 1.744, 95% CI 1.044-2.914, P = 0.034) and serum uric acid (OR 1.008, 95% CI 1.006-1.010, P ≤ 0.001) were independent risk factors for reduced eGFR.
Conclusions:
CKD is common and has a high prevalence in the population with CAD. Several risk factors are known to simultaneously affect heart and kidney. The patients with CAD may be considered as a high-risk population for CKD.
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