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Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

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Related Experiment Video

Updated: May 24, 2026

Rapid Generation of Amyloid from Native Proteins In vitro

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Localized AL amyloidosis: a suicidal neoplasm?

Per Westermark¹

¹Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Per.Westermark@igp.uu.se

Upsala Journal of Medical Sciences

|February 17, 2012

Summary

Localized AL amyloidosis, or amyloidoma, is a distinct plasma cell neoplasm, not a pseudotumor. Its unique pathogenesis may involve toxic immunoglobulin light chain assemblies causing plasma cell death.

Area of Science:

Hematology
Oncology
Pathology

Background:

AL amyloidosis is typically systemic but can present as localized deposits.
Localized AL amyloidosis (amyloidoma) differs morphologically from systemic forms and involves clonal plasma cells.

Purpose of the Study:

To characterize localized AL amyloidosis as a true plasma cell neoplasm.
To explore potential differences in pathogenesis between localized and systemic AL amyloidosis.

Main Methods:

Review of existing literature and case reports on localized AL amyloidosis.
Comparative analysis of morphological and etiological features between localized and systemic AL amyloidosis.

Main Results:

Localized AL amyloidosis is identified as a plasma cell neoplasm, distinct from pseudotumors.

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Published on: October 20, 2017

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Last Updated: May 24, 2026

Rapid Generation of Amyloid from Native Proteins In vitro

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Published on: December 5, 2013

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

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Published on: October 20, 2017

The kappa to lambda light chain ratio in localized AL amyloidosis is nearly 1:1, contrasting with the systemic form.

Morphological differences, presence of clonal plasma cells, and giant cells characterize localized AL amyloidosis.

Conclusions:

Localized AL amyloidosis represents a distinct neoplastic entity.
Pathogenesis may differ from systemic AL amyloidosis, potentially involving toxic oligomeric immunoglobulin light chains inducing plasma cell apoptosis.