Related Experiment Video
Updated: May 24, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Influences on breastfeeding outcomes for healthy term and preterm/sick infants
Sharon L Perrella1, Julie Williams, Elizabeth A Nathan
1School of Biomedical, Biomolecular, and Chemical Sciences, The University of Western Australia, Crawley, Western Australia, Australia. perres01@student.uwa.edu.au
Insights
Breastfeeding duration was similar for healthy and sick/preterm infants. However, mothers who previously breastfed for less than six months or perceived breastfeeding as important were more likely to stop early.
Area of Science:
- Perinatal health
- Infant nutrition
- Maternal-infant bonding
Background:
- Understanding breastfeeding duration is crucial for infant health.
- Factors influencing breastfeeding cessation require further investigation.
Purpose of the Study:
- To investigate breastfeeding outcomes in healthy term and sick/preterm infants.
- To identify factors associated with the duration of breastfeeding.
Main Methods:
- Follow-up study of 87 sick/preterm and 92 healthy term infants.
- Data collected over 9 months post-discharge.
- Multivariable analysis used to identify influencing factors.
Main Results:
- No significant difference in breastfeeding duration between sick/preterm and healthy term infants after correcting for gestational age.
- Early breastfeeding cessation was associated with infants born <33 weeks gestation (HR=2.05).
- Mothers with prior breastfeeding duration <6 months (HR=3.67) and those perceiving breastfeeding as 'important' (HR=2.58) were more likely to cease breastfeeding early.
Conclusions:
- Maternal perception of breastfeeding importance and prior breastfeeding history <6 months negatively impact breastfeeding duration.
- Preterm infants born <33 weeks gestation have shorter breastfeeding durations.
- These modifiable factors can be addressed during prenatal and postnatal care to support longer breastfeeding.
Objective:
This study investigated breastfeeding outcomes and factors associated with duration of breastfeeding in cohorts of healthy term and sick/preterm infants.
Study Design:
Follow-up was conducted of 87 sick/preterm and 92 term healthy infants during the 9 months following discharge from two Western Australian hospitals.
Results:
When corrected for gestational age, breastfeeding duration did not differ between the entire cohort of sick/preterm and term healthy groups. Multivariable analysis showed that early cessation of breastfeeding was more likely for infants born at <33 weeks of gestation (hazard ratio [HR ]=2.05, 95% confidence interval [CI]=1.14-3.69), mothers who had previously breastfed for <6 months (HR=3.67, 95% CI=2.12-6.37), and for mothers who perceived breastfeeding to be important rather than very important (HR=2.58, 95% CI=1.59-4.20).
Conclusions:
Maternal perceptions of breastfeeding as "important" rather than "very important" and previous breastfeeding duration of <6 months are negatively associated with breastfeeding duration; these factors can be identified and addressed during pregnancy and in the postnatal period. Preterm infants born at <33 weeks of gestation have a shorter breastfeeding duration than those born at a later gestation.
Related Concept Videos
Development of Human Microbiota
Development of the Oral Microbiota
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Teratogenicity

