Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 24, 2026

Controlled Strain of 3D Hydrogels under Live Microscopy Imaging
07:41

Controlled Strain of 3D Hydrogels under Live Microscopy Imaging

Published on: December 4, 2020

Mechanical stretching for tissue engineering: two-dimensional and three-dimensional constructs.

Brandon D Riehl1, Jae-Hong Park, Il Keun Kwon

  • 1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA.

Tissue Engineering. Part B, Reviews
|February 17, 2012
PubMed
Summary

Mechanical cell stretching guides tissue engineering for enhanced functionality and strength. This review highlights its role in controlling cell behavior and developing mechanically robust tissues in 2D and 3D models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Orai1 is required for Ca<sup>2+</sup>-dependent plasma membrane repair and mechanoadaptation.

bioRxiv : the preprint server for biology·2026
Same author

A mechanically tunable photo-cured hydrogel system based on methacrylated collagen-keratin inter-penetrating networks for rapid and enhanced wound healing.

International journal of biological macromolecules·2026
Same author

Age-Dependent Chromatin Remodeling Drives Inflammatory Dysregulation in Tendon Cells.

bioRxiv : the preprint server for biology·2026
Same author

3D-printable, heat-resistant polycaprolactone-based polymer scaffold for sustained NO release in tissue engineering applications.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Harnessing Oxidized Alginate Microgels for Rapid and Self-Assembling Dental Tissue Organogenesis In Vitro and In Vivo.

Small science·2025
Same author

Sprayable, crosslinker-free, and in situ-forming Schiff-based hydrogels based on oxidized sodium alginate and carbohydrazide-modified gelatin for rapid hemostasis.

Carbohydrate polymers·2025

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Mechanical cell stretching influences cell growth, differentiation, and tissue organization.
  • Engineered tissues subjected to mechanical stretch exhibit improved functionality and strength compared to static controls.
  • Stretch stimulation offers a potent, minimally invasive method for guiding tissue development.

Purpose of the Study:

  • To review recent advancements in cell stretching techniques for tissue engineering.
  • To explore the application of mechanical stretch in controlling cellular processes like orientation, growth, and differentiation.
  • To discuss the development of mechanically functional tissues using both 2D and 3D cell stretching models.

Main Methods:

  • Review of studies utilizing 2D and 3D cell stretching setups.

More Related Videos

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

Related Experiment Videos

Last Updated: May 24, 2026

Controlled Strain of 3D Hydrogels under Live Microscopy Imaging
07:41

Controlled Strain of 3D Hydrogels under Live Microscopy Imaging

Published on: December 4, 2020

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

  • Analysis of custom stretching devices and mechanical bioreactors.
  • Examination of stretch mechanotransduction pathways in various cellular environments.

    • Main Results:

    • Cell stretching effectively controls cell orientation, growth, gene expression, and lineage commitment.
    • Successful tissue engineering of cardiac, muscle, vasculature, ligament, tendon, and bone tissues using mechanical stretch.
    • Identification of capabilities and limitations of current stretching devices and bioreactors.

    Conclusions:

    • Mechanical cell stretching is a key strategy for engineering mechanically functional tissues.
    • Further investigation into 3D stretch mechanotransduction is crucial for understanding tissue development.
    • Optimized, tissue-specific stretch regimens with biochemical feedback are essential for advanced tissue engineering protocols.