Polysaccharide and extracts from Lentinula edodes: structural features and antiviral activity
Related Experiment Video
Updated: May 24, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Vinicius Pires Rincão1, Kristie Aimi Yamamoto, Nágila Maria Pontes Silva Ricardo
1Departamento de Microbiologia, Universidade Estadual de Londrina, Rod, Celso Garcia Cid,, km 380, CEP: 86051-990, Londrina, Paraná, Brazil.
Background:
Lentinula edodes, known as shiitake, has been utilized as food, as well as, in popular medicine, moreover, compounds isolated from its mycelium and fruiting body have shown several therapeutic properties. The aim of this study was to determine the antiviral activity of aqueous (AqE) and ethanol (EtOHE) extracts and polysaccharide (LeP) from Lentinula edodes in the replication of poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BoHV-1).
Methods:
The time-of-addition assay was performed at the times -2, -1, 0, 1 and 2 h of the infection. The virucidal activity and the inhibition of viral adsorption were also evaluated. Plaque assay was used to monitor antiviral activity throughout.
Results:
The AqE and LeP were more effective when added at 0 h of infection, however, EtOHE was more effective at the times 1 h and 2 h of the infection. AqE, EtOHE and LeP showed low virucidal activity, and the inhibition of viral adsorption was not significant.
Conclusions:
The results allowed us to conclude that AqE, EtOHE and LeP act on the initial processes of the replication of both strains of virus.
More Related Videos
Related Concept Videos
Viral Structure
Subviral Agents
Inhibitors of Viral Protein Synthesis
Antifungal Agents
Biosynthesis of Polysaccharides
Cellulose and Pectic Polysaccharides
As a cell matures, its cell wall specializes according to its type. For example, the parenchyma cells of...

