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Updated: May 24, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

[Post-menopausal ovarian hyperthecosis].

A-L Castell¹, S Hieronimus, A Chevallier

¹Service d'endocrinologie, gynécologie et reproduction, hôpital l'Archet, CHU de Nice, 151 route de Saint-Antoine-Ginestière, Nice, France.

Gynecologie, Obstetrique & Fertilite

|February 17, 2012

Summary

This summary is machine-generated.

Ovarian hyperthecosis is a rare cause of post-menopausal hyperandrogenia. Surgical removal of ovaries confirmed the condition and stopped excess androgen production.

Related Experiment Videos

Last Updated: May 24, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

Area of Science:

Endocrinology
Gynecology
Reproductive Medicine

Background:

Ovarian hyperthecosis is an infrequent cause of post-menopausal hyperandrogenia.
Its pathophysiology is poorly understood, but insulin resistance and elevated luteinizing hormone (LH) may play a role, similar to polycystic ovarian syndrome.

Observation:

Four post-menopausal patients presented with hyperandrogenia.
High testosterone levels, enlarged ovaries without focal lesions, and metabolic syndrome suggested ovarian hyperthecosis.
Bilateral annexectomy was performed for diagnosis and treatment.

Findings:

Histological examination confirmed ovarian hyperthecosis, characterized by specific luteinized stromal cells.
The surgical intervention led to the complete cessation of inappropriate androgen secretion.

Implications:

This case series highlights the importance of considering ovarian hyperthecosis in post-menopausal women with hyperandrogenia.
Surgical management can effectively resolve androgen excess in these patients.
Further research into the pathophysiology of ovarian hyperthecosis is warranted.