Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Borderline Personality Disorder01:25

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Introduction to Psychological Disorders01:19

Introduction to Psychological Disorders

Abnormal behavior, often referred to as mental illness, results from changes in brain function that influence thought patterns, behaviors, and social interactions. Psychologists and psychiatrists typically assess abnormal behavior using three primary criteria: deviance, maladaptation, and personal distress, particularly when these traits persist over long periods.
Deviant Behavior
Deviance in behavior refers to actions or thought patterns that significantly diverge from societal norms or...
Antisocial Personality Disorder01:24

Antisocial Personality Disorder

Antisocial personality disorder is a chronic mental health condition characterized by persistent patterns of disregard for the rights and well-being of others. Individuals with antisocial personality disorder exhibit behaviors that include deceitfulness, impulsivity, irresponsibility, aggression, and a profound lack of empathy. These traits often manifest early in life and persist into adulthood, leading to significant personal, social, and legal consequences.
Behavioral Characteristics and...
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A wireless subdural-contained brain-computer interface with 65,536 electrodes and 1,024 channels.

Nature electronics·2026
Same author

A Single Institution Experience with Pancreatic Carcinoma: A Retrospective Study.

Indian journal of surgical oncology·2026
Same author

Minimally invasive approach for excision of left atrial myxoma-an 8-year single-center experience.

Indian journal of thoracic and cardiovascular surgery·2026
Same author

Innovative Technique for Single-Stage Phalloplasty with Complete Urethral Reconstruction for Micropenis and Perineal Hypospadias.

Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India·2026
Same author

Oral cancer in the era of precision medicine: molecular targets and technological innovations.

Scientific reports·2026
Same author

Role of electronic health record in stigma experiences, trust, and care decisions by women with history of pregnancy and substance use disorder: a qualitative study of perceptions of clinical note language.

Journal of the American Medical Informatics Association : JAMIA·2026

Related Experiment Video

Updated: May 24, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Structural brain abnormalities and suicidal behavior in borderline personality disorder.

Paul H Soloff1, Patrick Pruitt, Mohit Sharma

  • 1Department of Psychiatry, University of Pittsburgh School of Medicine, United States. soloffph@upmc.edu

Journal of Psychiatric Research
|February 17, 2012
PubMed
Summary
This summary is machine-generated.

Individuals with Borderline Personality Disorder (BPD) who attempt suicide show distinct brain structure differences. These brain abnormalities in gray matter may help differentiate suicide attempters and predict attempt lethality in BPD.

More Related Videos

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Related Experiment Videos

Last Updated: May 24, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Borderline Personality Disorder (BPD) is associated with structural brain abnormalities in regions regulating emotion and cognition.
  • These cognitive impairments increase vulnerability to suicidal behavior.
  • Neural circuits underlying suicidal behavior in BPD remain unclear.

Purpose of the Study:

  • To compare brain structure differences between BPD suicide attempters and non-attempters.
  • To investigate structural variations related to suicide attempt lethality in BPD.
  • To identify neural correlates of suicidal behavior in BPD.

Main Methods:

  • Structural MRI scans were acquired from 68 BPD subjects and 52 healthy controls (HC).
  • Voxel-based morphometry (VBM) with DARTEL in SPM5 was used to analyze gray matter concentration in predefined regions of interest (ROIs).
  • Analyses controlled for age and gender, with cluster extent correction (p < .001).

Main Results:

  • BPD suicide attempters exhibited significantly reduced gray matter in 8 of 9 ROIs compared to HC.
  • Non-attempters showed reduced gray matter in 5 of 9 ROIs compared to HC.
  • Within the BPD group, attempters had less gray matter in the left insula compared to non-attempters; high lethality attempters showed further reductions in multiple brain regions.

Conclusions:

  • Specific structural brain abnormalities differentiate BPD suicide attempters from non-attempters.
  • Distinct patterns of gray matter reduction correlate with suicide attempt lethality in BPD.
  • These findings highlight potential neurobiological markers for suicidal behavior in BPD.