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Updated: May 24, 2026
09:20
Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
Published on: August 10, 2017
HDAC modulation and cell death in the clinic.
Carmela Dell'Aversana1, Ilaria Lepore, Lucia Altucci
1CNR-IGB Via P. Castellino 111, 80131, Napoli, Italy.
Experimental Cell Research
|February 17, 2012
Summary
Histone deacetylase inhibitors (HDACis) offer a reversible approach to cancer treatment by targeting epigenetic alterations. This review explores HDACis
Area of Science:
- Epigenetics and Molecular Biology
- Cancer Research
- Pharmacology
Background:
- Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylation, impacting chromatin structure and gene expression.
- Aberrant histone acetylation is linked to cancer development and progression.
- Epigenetic modifications, unlike genetic mutations, are potentially reversible, offering therapeutic opportunities.
Purpose of the Study:
- To review the biological characteristics of histone deacetylase inhibitors (HDACis).
- To analyze the mechanisms of action of HDACis.
- To discuss the current clinical applications of HDACis in cancer treatment.
Main Methods:
- Literature review of HDAC inhibitors.
- Analysis of molecular mechanisms of HDAC inhibition.
- Summary of clinical trial data and approved uses of HDACis.
Main Results:
- HDACis modulate gene expression by altering histone acetylation patterns.
- HDACis have demonstrated efficacy in various preclinical cancer models.
- Several HDACis are approved for treating specific cancers, with ongoing research for broader applications.
Conclusions:
- HDAC inhibitors represent a promising class of epigenetic drugs for cancer therapy.
- Understanding HDACi mechanisms is crucial for optimizing their clinical use.
- Further research into HDACis may expand their therapeutic potential in oncology.
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