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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Non-coding transcription characterization and annotation: a guide and web resource for non-coding RNA databases.

Alexandre Rossi Paschoal1, Vinicius Maracaja-Coutinho, João Carlos Setubal

  • 1Engenharia da Computação, Universidade Tecnológica Federal do Paraná-Campus Cornélio Procópio, Cornélio Procópio, Brazil.

RNA Biology
|February 17, 2012
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) play crucial roles in biology. A new resource, NRDR, helps researchers navigate the growing number of specialized ncRNA databases for efficient information retrieval.

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Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions
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Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

Published on: September 28, 2017

Related Experiment Videos

Last Updated: May 24, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions
10:52

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

Published on: September 28, 2017

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Large-scale transcriptome projects reveal a vast number of non-coding RNA (ncRNA) transcripts.
  • ncRNAs are increasingly recognized for their critical roles in diverse biological processes.
  • High-throughput technologies generate extensive ncRNA data across various organisms and experimental methods.

Purpose of the Study:

  • To address the challenge of integrating information from a rapidly expanding landscape of specialized ncRNA databases.
  • To introduce NRDR (Non-coding RNA Databases Resource), a centralized platform for ncRNA database retrieval.
  • To facilitate efficient searching and discovery of relevant ncRNA information for researchers.

Main Methods:

  • Conducted a comprehensive survey of 102 public ncRNA databases.
  • Developed a four-category classification system for databases: RNA family, information source, information content, and search mechanisms.
  • Implemented NRDR as a user-friendly web resource (www.ncrnadatabases.org).

Main Results:

  • Identified and cataloged 102 public databases dedicated to ncRNAs.
  • Established a structured classification system to aid database navigation.
  • NRDR provides a searchable interface for accessing curated information on ncRNA databases.

Conclusions:

  • NRDR serves as a valuable tool for researchers investigating ncRNAs.
  • The resource simplifies the process of locating and utilizing specialized ncRNA databases.
  • Facilitates advancements in ncRNA research by improving data accessibility and integration.