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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: May 24, 2026

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Laser peripheral iridoplasty for angle-closure.

Wai Siene Ng1, Ghee Soon Ang, Augusto Azuara-Blanco

  • 1c/o Cochrane Eyes andVision, ICEH, London School ofHygiene&TropicalMedicine, London,UK. waisiene@doctors.org.uk.

The Cochrane Database of Systematic Reviews
|February 17, 2012
PubMed
Summary
This summary is machine-generated.

Laser peripheral iridoplasty is not superior to laser iridotomy alone for treating angle-closure glaucoma. Current evidence does not strongly support its use in non-acute situations.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Surgical Interventions

Background:

  • Angle-closure glaucoma is a major cause of irreversible blindness globally.
  • Treatments aim to open the anterior chamber angle and reduce intraocular pressure (IOP).
  • Laser iridotomy is a primary treatment, but laser peripheral iridoplasty is an option when iridotomy fails.

Purpose of the Study:

  • To evaluate the effectiveness of laser peripheral iridoplasty versus other interventions for non-acute angle-closure.
  • The review included patients with narrow angles, primary angle-closure (PAC), or primary angle-closure glaucoma (PACG).

Main Methods:

  • Systematic search of multiple databases including CENTRAL, MEDLINE, EMBASE, LILACS, mRCT, ClinicalTrials.gov, and ICTRP.
  • Inclusion of only randomized controlled trials (RCTs) comparing laser peripheral iridoplasty with other treatments in non-acute settings.
  • Exclusion of studies focusing on acute angle-closure crisis.

Main Results:

  • One RCT with 158 participants was included.
  • Laser peripheral iridoplasty was studied as an adjunct to laser iridotomy.
  • No significant superiority was found for the combined approach regarding IOP, medication needs, or surgical intervention.

Conclusions:

  • The current evidence base is insufficient to strongly support the use of laser peripheral iridoplasty in treating angle-closure.
  • Further high-quality RCTs are needed to establish the efficacy of this intervention.