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Related Experiment Video

Updated: May 24, 2026

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

Published on: October 18, 2024

Interventions for erosive lichen planus affecting mucosal sites.

Suzanne Cheng¹, Gudula Kirtschig, Susan Cooper

¹Department of Dermatology, Queen’s Medical Centre, Nottingham, UK.

The Cochrane Database of Systematic Reviews

|February 17, 2012

Summary

Evidence for treatments for erosive lichen planus (ELP) is limited, with no effective therapies identified for genital ELP. Further large-scale randomized controlled trials (RCTs) are needed to establish effective treatments for oral and genital ELP.

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Last Updated: May 24, 2026

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

Published on: October 18, 2024

Area of Science:

Dermatology
Autoimmune Diseases
Clinical Trials

Background:

Erosive lichen planus (ELP) is a chronic, painful autoimmune condition affecting mucosal surfaces.
Treatment for ELP is challenging, focusing on symptom management rather than cure.
Existing interventions for ELP have shown variable results.

Purpose of the Study:

To evaluate the efficacy of various interventions for erosive lichen planus (ELP) in the oral, anogenital, and esophageal regions.
To synthesize findings from randomized controlled trials (RCTs) assessing treatments for ELP.

Main Methods:

A comprehensive literature search was conducted across multiple databases up to September 2009.
Included all randomized controlled trials (RCTs) evaluating topical or systemic treatments for ELP in any region.
Primary outcomes included pain reduction (visual analogue scale), physician, and participant global assessments.

Main Results:

Fifteen RCTs involving 473 participants with oral ELP were analyzed; no studies included genital or esophageal ELP.
Data could not be pooled due to heterogeneity in interventions, study design, and outcomes.
Some interventions like clobetasol propionate, ciclosporin, aloe vera, and pimecrolimus showed potential benefits in small subgroups, but overall evidence for any single treatment, including topical steroids, was weak.

Conclusions:

There is limited evidence supporting the effectiveness of current treatments for oral ELP, and no evidence for genital ELP.
Larger-scale RCTs with standardized, clinically relevant outcome measures are necessary for both oral and genital ELP.
Development of validated, combined severity scoring tools for oral and genital ELP is recommended.