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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Obedience01:08

Obedience

According to obedience research, we may harm others under the forceful pressures of an authority figure (Milgram, 1974). How about if the inappropriate orders were delivered with less force? The increasing interdependence between nurses and physicians compelled Hofling and his colleagues to explore nurses’ reactions to a potentially harmful medical request made by the perceived authority figure, the doctor (Hofling, Brotzman, Dalrymple, Graves, & Pierce, 1966). In this situation, obedience...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Nursing Ethical Principles II01:27

Nursing Ethical Principles II

Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's cancer...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...

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Related Experiment Video

Updated: May 24, 2026

A Rat Model of Compound Acne
03:10

A Rat Model of Compound Acne

Published on: November 1, 2024

The noncompliant patient with acne.

E A Tanghetti1

  • 1Center for Dermatology and Laser Surgery, Sacramento, CA, USA.

Skin Therapy Letter
|February 17, 2012
PubMed
Summary

Patient adherence significantly impacts acne treatment success, often preventing favorable outcomes seen in clinical studies. Strategies like adjusting dosages and using laser/light devices can help manage nonadherent patients.

Area of Science:

  • Dermatology
  • Clinical Medicine
  • Pharmacology

Background:

  • Acne treatments, both topical and systemic, demonstrate significant efficacy in clinical trials over 3-month periods.
  • Despite proven effectiveness, achieving comparable results in clinical practice is often challenging.
  • Patient nonadherence is identified as a primary barrier to successful acne treatment outcomes.

Purpose of the Study:

  • To review the problem of patient nonadherence in acne treatment.
  • To offer practical suggestions for managing nonadherent patients.
  • To explore strategies including dosing adjustments and adjunctive therapies like laser/light devices.

Main Methods:

  • Review of clinical experience and recent published data on acne treatment adherence.

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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  • Analysis of factors contributing to nonadherence.
  • Identification and discussion of therapeutic modifications.

    • Main Results:

    • Nonadherence is a critical factor limiting the effectiveness of acne therapies in real-world settings.
    • Specific patient management strategies can potentially improve treatment outcomes.
    • Adjusting medication schedules and incorporating device-based treatments are viable options.

    Conclusions:

    • Improving patient adherence is crucial for optimizing acne treatment results.
    • Tailoring treatment plans to address nonadherence is essential for clinical success.
    • Innovative approaches, including device-assisted therapies, offer promise for nonadherent individuals.